Resequencing and signatures of selection scan in two Siberian native sheep breeds point to candidate genetic variants for adaptation and economically important traits

J. Sweet-Jones, A. A. Yurchenko, A. V. Igoshin, N. S. Yudin, M. T. Swain, D. M. Larkin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (SciVal)
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Abstract

Russian sheep breeds represent an important economic asset by providing meat and wool, whilst being adapted to extreme climates. By resequencing two Russian breeds from Siberia: Tuva (n = 20) and Baikal (n = 20); and comparing them with a European (UK) sheep outgroup (n = 14), 41 million variants were called, and signatures of selection were identified. High-frequency missense mutations on top of selection peaks were found in genes related to immunity (LOC101109746) in the Baikal breed and wool traits (IDUA), cell differentiation (GLIS1) and fat deposition (AADACL3) in the Tuva breed. In addition, genes found under selection owing to haplotype frequency changes were related to wool traits (DSC2), parasite resistance (CLCA1), insulin receptor pathway (SOCS6) and DNA repair (DDB2) in the Baikal breed, and vision (GPR179) in the Tuva breed. Our results present candidate genes and SNPs for future selection programmes, which are necessary to maintain and increase socioeconomic gain from Siberian breeds.

Original languageEnglish
Pages (from-to)126-131
Number of pages6
JournalAnimal Genetics
Volume52
Issue number1
Early online date27 Oct 2020
DOIs
Publication statusPublished - 13 Jan 2021

Keywords

  • local breeds
  • selection
  • sheep
  • whole-genome resequencing
  • Sheep/genetics
  • Adaptation, Physiological/genetics
  • Phenotype
  • Animals
  • Breeding
  • Siberia
  • Polymorphism, Single Nucleotide
  • Mutation, Missense

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