Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Moses Egesa; Karl Hoffmann; Cornelis H. Hokke; Maria Yazdanbakhsh; Stephen Cose

doi:10.1016/j.pt.2017.07.007

Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Moses Egesa, Karl Hoffmann, Cornelis H. Hokke, Maria Yazdanbakhsh, Stephen Cose

Department of Life Sciences

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Abstract

There is currently no vaccine against schistosomiasis. With few Schistosoma vaccine candidates in clinical trials, unexplored antigens from the vulnerable schistosomulum should be considered as possible vaccine candidates. In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic schistosomula vaccine candidates.

Original language	English
Article number	1671
Pages (from-to)	918-921
Number of pages	4
Journal	Trends in Parasitology
Volume	33
Issue number	12
Early online date	14 Aug 2017
DOIs	https://doi.org/10.1016/j.pt.2017.07.007
Publication status	Published - 01 Dec 2017

Keywords

Schistosoma
adjuvant
delivery
schistosomula
synthetic vesicles
vaccine candidates
Schistosoma mansoni/metabolism
Schistosomiasis/prevention & control
Animals
Vaccines/administration & dosage
Humans
Antigens, Helminth/immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.pt.2017.07.007

Rethinking Schistosomiasis Vaccine Development: Synthetic VesiclesAccepted author manuscript, 1.05 MB

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title = "Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles",

abstract = "There is currently no vaccine against schistosomiasis. With few Schistosoma vaccine candidates in clinical trials, unexplored antigens from the vulnerable schistosomulum should be considered as possible vaccine candidates. In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic schistosomula vaccine candidates.",

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author = "Moses Egesa and Karl Hoffmann and Hokke, {Cornelis H.} and Maria Yazdanbakhsh and Stephen Cose",

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AU - Egesa, Moses

AU - Hoffmann, Karl

AU - Hokke, Cornelis H.

AU - Yazdanbakhsh, Maria

AU - Cose, Stephen

PY - 2017/12/1

Y1 - 2017/12/1

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AB - There is currently no vaccine against schistosomiasis. With few Schistosoma vaccine candidates in clinical trials, unexplored antigens from the vulnerable schistosomulum should be considered as possible vaccine candidates. In addition, we suggest developing synthetic vesicles as a new delivery vehicle and adjuvant for immunoprophylactic schistosomula vaccine candidates.

KW - Schistosoma

KW - adjuvant

KW - delivery

KW - schistosomula

KW - synthetic vesicles

KW - vaccine candidates

KW - Schistosoma mansoni/metabolism

KW - Schistosomiasis/prevention & control

KW - Animals

KW - Vaccines/administration & dosage

KW - Humans

KW - Antigens, Helminth/immunology

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M3 - Article

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EP - 921

JO - Trends in Parasitology

JF - Trends in Parasitology

IS - 12

M1 - 1671

ER -

Rethinking Schistosomiasis Vaccine Development: Synthetic Vesicles

Abstract

Keywords

UN SDGs

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