RNA-based biocontrol compounds: Current status and perspectives to reach the market

Clauvis Nji Tizi Taning, Salvatore Arpaia, Olivier Christiaens, Antje Dietz-Pfeilstetter, Huw Jones, Bruno Mezzetti, Silvia Sabbadini, Hilde-Gunn Opsahl Hoen-Sorteberg, Jeremy Sweet, Vera Ventura, Guy Smagghe

Research output: Contribution to journalArticlepeer-review

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Facing current climate challenges and drastically reduced chemical options for plant protection, the exploitation of RNA interference (RNAi) as an agricultural biotechnology tool has unveiled possible new solutions to the global problems of agricultural losses caused by pests and other biotic and abiotic stresses. While the use of RNAi as a tool in agriculture is still limited to a few transgenic crops, and only adopted in restricted parts of the world, scientists and industry are already seeking innovations in leveraging and exploiting the potential of RNAi in the form of RNA-based biocontrol compounds for external applications. Here, we highlight the expanding research and development pipeline, commercial landscape and regulatory environment surrounding the pursuit of RNA-based biocontrol compounds with improved environmental profiles. The commitments of well-established agrochemical companies to invest in research endeavours and the role of start-up companies are crucial for the successful development of practical applications for these compounds. Additionally, the availability of standardized guidelines to tackle regulatory ambiguities surrounding RNA-based biocontrol compounds will help to facilitate the entire commercialization process. Finally, communication to create awareness and public acceptance will be key to the deployment of these compounds.

Original languageEnglish
Pages (from-to)841-845
Number of pages5
JournalPest Management Science
Issue number3
Early online date19 Nov 2019
Publication statusPublished - 11 Feb 2020


  • RNA interference
  • biocontrol
  • biosafety
  • biotechnology
  • dsRNA
  • regulatory


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