TY - JOUR
T1 - Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis
AU - Kell, Douglas B.
AU - Pritchard, Leighton
N1 - Pritchard, L., Kell, D. B. (2002). Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis. European Journal of Biochemistry, 269, (16), 3894-3904.
PY - 2002/8/5
Y1 - 2002/8/5
N2 - We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control.
AB - We used parameter scanning to emulate changes to the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two of which were under the dominant control of hexose transport, in accordance with various experimental studies and other model predictions. A third control regime in which phosphofructokinase exerted dominant glycolytic flux control was also found, but it appeared to be physiologically unreachable by this model, and all realistically obtainable flux control regimes featured hexose transport as a step involving high flux control.
U2 - 10.1046/j.1432-1033.2002.03055.x
DO - 10.1046/j.1432-1033.2002.03055.x
M3 - Article
SN - 1742-4658
VL - 269
SP - 3894
EP - 3904
JO - European Journal of Biochemistry
JF - European Journal of Biochemistry
IS - 16
ER -