Sequence and analysis of chromosome 2 of Dictyostelium discoideum

Gernot Glöckner, Ludwig Eichinger, Karol Szafranski, Justin A Pachebat, Alan T Bankier, Paul H Dear, Rüdiger Lehmann, Cornelia Baumgart, Genís Parra, Josep F Abril, Roderic Guigó, Kai Kumpf, Budi Tunggal, Edward Cox, Michael A Quail, Matthias Platzer, André Rosenthal, Angelika A Noegel, Bart G. Barrell, Marie-Adèle RajandreamJeffrey G. Williams, Robert R. Kay, Adam Kuspa, Richard Gibbs, Richard Sucgang, Donna M. Muzny, Brian Desany, Kathy Zeng, Baoli Zhu, Pieter de Jong, Theodor Dingermann, Günther Gerisch, Peter Philippsen, Michael Schleicher, Thomas Winckler

Research output: Contribution to journalArticlepeer-review

155 Citations (SciVal)

Abstract

The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of the genome. Despite an A + T content of nearly 80%, the chromosome codes for 2,799 predicted protein coding genes and 73 transfer RNA genes. This gene density, about 1 gene per 2.6 kilobases (kb), is surpassed only by Saccharomyces cerevisiae (one per 2 kb) and is similar to that of Schizosaccharomyces pombe (one per 2.5 kb). If we assume that the other chromosomes have a similar gene density, we can expect around 11,000 genes in the D. discoideum genome. A significant number of the genes show higher similarities to genes of vertebrates than to those of other fully sequenced eukaryotes. This analysis strengthens the view that the evolutionary position of D. discoideum is located before the branching of metazoa and fungi but after the divergence of the plant kingdom, placing it close to the base of metazoan evolution.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalNature
Volume418
Issue number6893
DOIs
Publication statusPublished - 04 Jul 2002

Keywords

  • Animals
  • Base Composition
  • Chromosomes
  • Chromosomes, Artificial, Yeast
  • Dictyostelium
  • Evolution, Molecular
  • Genes, Fungal
  • Genes, Plant
  • Genes, Protozoan
  • Humans
  • Phylogeny
  • Physical Chromosome Mapping
  • Protein Structure, Tertiary
  • Protozoan Proteins
  • RNA, Transfer
  • Sequence Analysis, DNA
  • Sequence Homology
  • Vertebrates

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