Shedding of Mycobacterium bovis in the nasal mucus of cattle infected experimentally with tuberculosis by the intranasal and intratracheal routes

T. McCorry, A. O. Whelan, M. D. Welsh*, J. McNair, E. Walton, D. G. Bryson, R. G. Hewinson, H. M. Vordermeier, J. M. Pollock

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (SciVal)

Abstract

Four groups of six calves were infected experimentally with either a low dose of approximately 104 colony-forming units (cfu) or a high dose of approximately 106 cfu of Mycobacterium bovis. Each dose was delivered by the intranasal and intratracheal routes. More severe disease was observed in the groups inoculated with the high dose. Visible lesions were identified in 21 of the 24 animals, all of which also gave positive skin tests and interferon-γ (IFN-γ) responses. Nasal shedding was detected in 15 of the 24 animals and the frequency of shedding was influenced by both the route and the dose of infection; no shedding was observed in the group infected intratracheally with the low dose. Two of the 15 confirmed shedders had no visible lesions at postmortem examination; both of these calves gave IFN-γ responses but only one was skin test positive.

Original languageEnglish
Pages (from-to)613-618
Number of pages6
JournalVeterinary Record
Volume157
Issue number20
DOIs
Publication statusPublished - 12 Nov 2005

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