Stain Colour Normalisation to Improve Mitosis Detection on Breast Histology Images

Azam Hamidinekoo, Reyer Zwiggelaar

Research output: Chapter in Book/Report/Conference proceedingConference Proceeding (Non-Journal item)

5 Citations (Scopus)

Abstract

The mitosis count, one of the main components considered for grading breast cancer on histology images, is used to assess tumour proliferation. On breast histology sections, different coloured stains are used to highlight existing cellular components. To keep the wealth of information in the stain colour representation and decrease the sensitivity of detection and classification models to stain variations, the RGB Histogram Specification method is used as a preprocessing step in the training of a modified deep convolutional neural network. Different models are trained on raw and stain normalised images using different databases. Evaluation results show more stable detection performance for various imaging conditions. Combining different data sources and employing stain colour normalisation and transfer learning, a network is trained that can be used for the general mitosis detection task and dealing with staining and scanner variations.
Original languageEnglish
Title of host publicationDeep Learning in Medical Image Analysis and Multimodal Learning for Clinical Decision Support - 3rd International Workshop, DLMIA 2017 and 7th International Workshop, ML-CDS 2017 Held in Conjunction with MICCAI 2017, Proceedings
Subtitle of host publicationThird International Workshop, DLMIA 2017, and 7th International Workshop, ML-CDS 2017, Held in Conjunction with MICCAI 2017, Québec City, QC, Canada, September 14, Proceedings
EditorsM. Jorge Cardoso, Tal Arbel, Gustavo Carneiro, João Manuel R.S. Tavares, Mehdi Moradi, Andrew Bradley, Hayit Greenspan, João Paulo Papa, Arnant Madabhushi, Jacinto C. Nascimento, Jaime S. Cardoso, Vasileios Belagiannis, Zhi Lu
PublisherSpringer Nature
Pages213-221
Number of pages9
ISBN (Electronic)978-3-319-67558-9
ISBN (Print)978-3-319-67557-2
DOIs
Publication statusPublished - 09 Sept 2017
EventThird International Workshop, DLMIA 2017, and 7th International Workshop, ML-CDS 2017, Held in Conjunction with MICCAI 2017 - Québec City, Canada
Duration: 14 Sept 2017 → …

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume10553 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

ConferenceThird International Workshop, DLMIA 2017, and 7th International Workshop, ML-CDS 2017, Held in Conjunction with MICCAI 2017
Country/TerritoryCanada
CityQuébec City
Period14 Sept 2017 → …

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