TY - JOUR
T1 - Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals
AU - Woodman, Sally
AU - Gibson, Amanda J.
AU - García, Ana Rubio
AU - Contreras, Guillermo Sanchez
AU - Rossen, John W.
AU - Werling, Dirk
AU - Offord, Victoria
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Pinnipeds are a diverse clade of semi-aquatic mammals, which act as key indicators of ecosystem health. Their transition from land to marine environments provides a complex microbial milieu, making them vulnerable to both aquatic and terrestrial pathogens, thereby contributing to pinniped population decline. Indeed, viral pathogens such as influenza A virus and phocine distemper virus (PDV) have been identified as the cause of several of these mass mortality events. Furthermore, bacterial infection with mammalian Brucella sp. and methicillin-resistant Staphylococcus aureus strains have also been observed in marine mammals, posing further risk to both co-habiting endangered species and public health. During these disease outbreaks, mortality rates have varied amongst different pinniped species. Analyses of innate immune receptors at the host-pathogen interface have previously identified variants which may drive these species-specific responses. Through a combination of both sequence- and structure-based methods, this study characterises members of the Toll-like receptor (TLR) 1 superfamily from both harbour and elephant seals, identifying variations which will help us to understand these species-specific innate immune responses, potentially aiding the development of specific vaccine-adjuvants for these species.
AB - Pinnipeds are a diverse clade of semi-aquatic mammals, which act as key indicators of ecosystem health. Their transition from land to marine environments provides a complex microbial milieu, making them vulnerable to both aquatic and terrestrial pathogens, thereby contributing to pinniped population decline. Indeed, viral pathogens such as influenza A virus and phocine distemper virus (PDV) have been identified as the cause of several of these mass mortality events. Furthermore, bacterial infection with mammalian Brucella sp. and methicillin-resistant Staphylococcus aureus strains have also been observed in marine mammals, posing further risk to both co-habiting endangered species and public health. During these disease outbreaks, mortality rates have varied amongst different pinniped species. Analyses of innate immune receptors at the host-pathogen interface have previously identified variants which may drive these species-specific responses. Through a combination of both sequence- and structure-based methods, this study characterises members of the Toll-like receptor (TLR) 1 superfamily from both harbour and elephant seals, identifying variations which will help us to understand these species-specific innate immune responses, potentially aiding the development of specific vaccine-adjuvants for these species.
KW - Conservation
KW - Evolution
KW - Pinniped
KW - Toll-like receptor
KW - Zoonosis
UR - http://www.scopus.com/inward/record.url?scp=84960353330&partnerID=8YFLogxK
U2 - 10.1016/j.vetimm.2015.11.006
DO - 10.1016/j.vetimm.2015.11.006
M3 - Article
C2 - 26827833
AN - SCOPUS:84960353330
SN - 0165-2427
VL - 169
SP - 10
EP - 14
JO - Veterinary Immunology and Immunopathology
JF - Veterinary Immunology and Immunopathology
ER -