TY - JOUR
T1 - Synergism between bacterial GAPDH and OMVs: disparate mechanisms but co-operative action
AU - Whitworth, David
AU - Morgan, Bethan
PY - 2015/11/9
Y1 - 2015/11/9
N2 - Outer membrane vesicles (OMVs) shed from bacteria contribute to pathogenesis by promoting colonization of host tissues and trafficking virulence factors into host cells via fusion with the host cell plasma membrane. Glyeraldehyde-3-phosphate dehydrogenase (GAPDH) is also secreted by prokaryotes, but enhances pathogenesis by promoting adhesion of bacteria to host cell surfaces. However, GAPDH is also known to catalyze the fusion of membranes, and it has been shown to promote OMV activity in the non-pathogen Myxococcus xanthus. We suggest that during infection by Gram-negative bacteria, GAPDH and OMVs work synergistically to stimulate pathogenesis.
AB - Outer membrane vesicles (OMVs) shed from bacteria contribute to pathogenesis by promoting colonization of host tissues and trafficking virulence factors into host cells via fusion with the host cell plasma membrane. Glyeraldehyde-3-phosphate dehydrogenase (GAPDH) is also secreted by prokaryotes, but enhances pathogenesis by promoting adhesion of bacteria to host cell surfaces. However, GAPDH is also known to catalyze the fusion of membranes, and it has been shown to promote OMV activity in the non-pathogen Myxococcus xanthus. We suggest that during infection by Gram-negative bacteria, GAPDH and OMVs work synergistically to stimulate pathogenesis.
UR - http://hdl.handle.net/2160/30441
U2 - 10.3389/fmicb.2015.01231
DO - 10.3389/fmicb.2015.01231
M3 - Article
C2 - 26617577
SN - 1664-302X
VL - 6
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
M1 - 1231
ER -