Synthesis of (+)-(R)-Tiruchanduramine

Zahraa S. Al-Taie, Barbara Bartholomew, Christopher Cartmell, Richard T. Froom, Russell G. Kerr, Rolf Kraehenbuehl, Patrick J. Murphy*, Robert J. Nash, Yana B. Penkova, Alexander van Teijlingen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The absolute stereochemistry of the marine alkaloid (+)-(R)-tiruchanduramine was established via a convergent total synthesis in six steps and 15.5% overall yield from Fmoc-D-Dab(Boc)-OH.

Original languageEnglish
Article number1338
Pages (from-to)e1338
JournalMolecules
Volume27
Issue number4
DOIs
Publication statusPublished - 16 Feb 2022

Keywords

  • Guanidines
  • Synoicum macroglossum
  • Tiruchanduramine
  • β-carboline
  • Chemistry Techniques, Synthetic
  • Combinatorial Chemistry Techniques
  • Molecular Structure
  • Alkaloids/chemical synthesis

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