Targeting the Bacterial Protective Armour: Challenges and Novel Strategies in the Treatment of Microbial Biofilm

Nor Kamaruzzaman, Li Tan, Khairun Mat Yazid, Shamsaldeen Saeed, Ruhil Hamdan, Siew Choong, Weng Wong, Alexandru Chivu, Amanda Gibson

Research output: Contribution to journalReview Articlepeer-review

28 Citations (SciVal)
75 Downloads (Pure)

Abstract

Infectious disease caused by pathogenic bacteria continues to be the primary challenge to humanity. Antimicrobial resistance and microbial biofilm formation in part, lead to treatment failures. The formation of biofilms by nosocomial pathogens such as Staphylococcus aureus (S. aureus), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumoniae (K. pneumoniae) on medical devices and on the surfaces of infected sites bring additional hurdles to existing therapies. In this review, we discuss the challenges encountered by conventional treatment strategies in the clinic. We also provide updates on current on-going research related to the development of novel anti-biofilm technologies. We intend for this review to provide understanding to readers on the current problem in health-care settings and propose new ideas for new intervention strategies to reduce the burden related to microbial infections.
Original languageEnglish
Article number1705
Number of pages27
JournalMaterials
Volume11
Issue number9
DOIs
Publication statusPublished - 13 Sept 2018

Keywords

  • Anti-biofilms
  • Biofilms
  • Klebsiella pneumoniae
  • Nosocomial pathogens
  • Pseudomonas aeruginosa
  • Staphylococcus aureus

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