Temperature-dependent expression of the chromosomal β-lactamase gene in a strain of Pseudomonas aeruginosa

R. G. Hewinson; W. W. Nichols

doi:10.1099/00222615-24-3-263

Temperature-dependent expression of the chromosomal β-lactamase gene in a strain of Pseudomonas aeruginosa

R. G. Hewinson, W. W. Nichols

Bovine TB, diseases and control

University of Oxford

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A strain of Pseudomonas aeruginosa (3-Post) was resistant to cefsulodin and ceftazidime at 37°C but sensitive at 20°C. Resistance was mediated by chromosomally-encoded β lactamase which was synthesised at a high level during growth above 30°C but at a low, inducible level during growth below 27°C.

Original language	English
Pages (from-to)	263-265
Number of pages	3
Journal	Journal of Medical Microbiology
Volume	24
Issue number	3
DOIs	https://doi.org/10.1099/00222615-24-3-263
Publication status	Published - 01 Nov 1987

Keywords

Cefsulodin/pharmacology
Ceftazidime/pharmacology
Cephalosporins/metabolism
Chromosomes, Bacterial/physiology
Drug Resistance, Microbial
Gene Expression Regulation
Pseudomonas aeruginosa/drug effects
Temperature
beta-Lactamases/genetics

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title = "Temperature-dependent expression of the chromosomal β-lactamase gene in a strain of Pseudomonas aeruginosa",

abstract = "A strain of Pseudomonas aeruginosa (3-Post) was resistant to cefsulodin and ceftazidime at 37°C but sensitive at 20°C. Resistance was mediated by chromosomally-encoded β lactamase which was synthesised at a high level during growth above 30°C but at a low, inducible level during growth below 27°C.",

keywords = "Cefsulodin/pharmacology, Ceftazidime/pharmacology, Cephalosporins/metabolism, Chromosomes, Bacterial/physiology, Drug Resistance, Microbial, Gene Expression Regulation, Pseudomonas aeruginosa/drug effects, Temperature, beta-Lactamases/genetics",

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AU - Hewinson, R. G.

AU - Nichols, W. W.

PY - 1987/11/1

Y1 - 1987/11/1

N2 - A strain of Pseudomonas aeruginosa (3-Post) was resistant to cefsulodin and ceftazidime at 37°C but sensitive at 20°C. Resistance was mediated by chromosomally-encoded β lactamase which was synthesised at a high level during growth above 30°C but at a low, inducible level during growth below 27°C.

AB - A strain of Pseudomonas aeruginosa (3-Post) was resistant to cefsulodin and ceftazidime at 37°C but sensitive at 20°C. Resistance was mediated by chromosomally-encoded β lactamase which was synthesised at a high level during growth above 30°C but at a low, inducible level during growth below 27°C.

KW - Cefsulodin/pharmacology

KW - Ceftazidime/pharmacology

KW - Cephalosporins/metabolism

KW - Chromosomes, Bacterial/physiology

KW - Drug Resistance, Microbial

KW - Gene Expression Regulation

KW - Pseudomonas aeruginosa/drug effects

KW - Temperature

KW - beta-Lactamases/genetics

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DO - 10.1099/00222615-24-3-263

M3 - Article

C2 - 3118037

AN - SCOPUS:0023199550

SN - 0022-2615

VL - 24

SP - 263

EP - 265

JO - Journal of Medical Microbiology

JF - Journal of Medical Microbiology

IS - 3

ER -

Temperature-dependent expression of the chromosomal β-lactamase gene in a strain of Pseudomonas aeruginosa

Abstract

Keywords

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