TY - JOUR
T1 - The complete genome sequence of Mycobacterium bovis
AU - Garnier, Thierry
AU - Eiglmeier, Karin
AU - Camus, Jean Christophe
AU - Medina, Nadine
AU - Mansoor, Huma
AU - Pryor, Melinda
AU - Duthoy, Stephanie
AU - Grondin, Sophie
AU - Lacroix, Celine
AU - Monsempe, Christel
AU - Simon, Sylvie
AU - Harris, Barbara
AU - Atkin, Rebecca
AU - Doggett, Jon
AU - Mayes, Rebecca
AU - Keating, Lisa
AU - Wheeler, Paul R.
AU - Parkhill, Julian
AU - Barrell, Bart G.
AU - Cole, Stewart T.
AU - Gordon, Stephen V.
AU - Hewinson, R. Glyn
PY - 2003/6/24
Y1 - 2003/6/24
N2 - Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and man, with worldwide annual losses to agriculture of $3 billion. The human burden of tuberculosis caused by the bovine tubercle bacillus is still largely unknown. M. bovis was also the progenitor for the M. bovis bacillus Calmette-Guérin vaccine strain, the most widely used human vaccine. Here we describe the 4,345,492-bp genome sequence of M. bovis AF2122/97 and its comparison with the genomes of Mycobacterium tuberculosis and Mycobacterium leprae. Strikingly, the genome sequence of M. bovis is >99.95% identical to that of M. tuberculosis, but deletion of genetic information has led to a reduced genome size. Comparison with M. leprae reveals a number of common gene losses, suggesting the removal of functional redundancy. Cell wall components and secreted proteins show the greatest variation, indicating their potential role in host-bacillus interactions or immune evasion. Furthermore, there are no genes unique to M. bovis, implying that differential gene expression may be the key to the host tropisms of human and bovine bacilli. The genome sequence therefore offers major insight on the evolution, host preference, and pathobiology of M. bovis.
AB - Mycobacterium bovis is the causative agent of tuberculosis in a range of animal species and man, with worldwide annual losses to agriculture of $3 billion. The human burden of tuberculosis caused by the bovine tubercle bacillus is still largely unknown. M. bovis was also the progenitor for the M. bovis bacillus Calmette-Guérin vaccine strain, the most widely used human vaccine. Here we describe the 4,345,492-bp genome sequence of M. bovis AF2122/97 and its comparison with the genomes of Mycobacterium tuberculosis and Mycobacterium leprae. Strikingly, the genome sequence of M. bovis is >99.95% identical to that of M. tuberculosis, but deletion of genetic information has led to a reduced genome size. Comparison with M. leprae reveals a number of common gene losses, suggesting the removal of functional redundancy. Cell wall components and secreted proteins show the greatest variation, indicating their potential role in host-bacillus interactions or immune evasion. Furthermore, there are no genes unique to M. bovis, implying that differential gene expression may be the key to the host tropisms of human and bovine bacilli. The genome sequence therefore offers major insight on the evolution, host preference, and pathobiology of M. bovis.
UR - http://www.scopus.com/inward/record.url?scp=0037596510&partnerID=8YFLogxK
U2 - 10.1073/pnas.1130426100
DO - 10.1073/pnas.1130426100
M3 - Article
C2 - 12788972
AN - SCOPUS:0037596510
SN - 0027-8424
VL - 100
SP - 7877
EP - 7882
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 13
ER -
