The effect of mycophenolic acid on the cell cycle of Candida albicans

Carmel M. Quinn; Virginia C. Bugeja; Joseph A. Gallagher; Peter A. Whittaker

doi:10.1007/BF02282799

The effect of mycophenolic acid on the cell cycle of Candida albicans

Carmel M. Quinn, Virginia C. Bugeja, Joseph A. Gallagher, Peter A. Whittaker

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Mycophenolic acid inhibited the growth ofCandida albicans. Cultures exposed to a concentration of 8.4 μg ml−1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis.

The results are discussed in relation to the possible mode of action of mycophenolic acid.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Mycopathologia
Volume	111
Issue number	3
DOIs	https://doi.org/10.1007/BF02282799
Publication status	Published - Sept 1990

Keywords

Candida albicans
mycophenolic acid
cell cycle

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abstract = "Mycophenolic acid inhibited the growth ofCandida albicans. Cultures exposed to a concentration of 8.4 μg ml−1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis.The results are discussed in relation to the possible mode of action of mycophenolic acid.",

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The effect of mycophenolic acid on the cell cycle of Candida albicans

Abstract

Keywords

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