The effect of mycophenolic acid on the cell cycle of Candida albicans

Carmel M. Quinn; Virginia C. Bugeja; Joseph A. Gallagher; Peter A. Whittaker

doi:10.1007/BF02282799

The effect of mycophenolic acid on the cell cycle of Candida albicans

Carmel M. Quinn
, Virginia C. Bugeja
, Joseph A. Gallagher
, Peter A. Whittaker

Institute of Biological, Environmental, and Rural Sciences

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Mycophenolic acid inhibited the growth ofCandida albicans. Cultures exposed to a concentration of 8.4 μg ml−1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis.

The results are discussed in relation to the possible mode of action of mycophenolic acid.

Original language	English
Pages (from-to)	165-168
Number of pages	4
Journal	Mycopathologia
Volume	111
Issue number	3
DOIs	https://doi.org/10.1007/BF02282799
Publication status	Published - Sept 1990

Keywords

Candida albicans
mycophenolic acid
cell cycle

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title = "The effect of mycophenolic acid on the cell cycle of Candida albicans",

abstract = "Mycophenolic acid inhibited the growth ofCandida albicans. Cultures exposed to a concentration of 8.4 μg ml−1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis. The results are discussed in relation to the possible mode of action of mycophenolic acid.",

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year = "1990",

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AU - Whittaker, Peter A.

PY - 1990/9

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N2 - Mycophenolic acid inhibited the growth ofCandida albicans. Cultures exposed to a concentration of 8.4 μg ml−1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis. The results are discussed in relation to the possible mode of action of mycophenolic acid.

AB - Mycophenolic acid inhibited the growth ofCandida albicans. Cultures exposed to a concentration of 8.4 μg ml−1 mycophenolic acid were found to exhibit cell cycle arrest with two or more buds. Nuclear staining revealed that these were nucleate implying a possible defect in cytokinesis. The results are discussed in relation to the possible mode of action of mycophenolic acid.

KW - Candida albicans

KW - mycophenolic acid

KW - cell cycle

UR - https://www.scopus.com/pages/publications/0025162526

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DO - 10.1007/BF02282799

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SP - 165

EP - 168

JO - Mycopathologia

JF - Mycopathologia

IS - 3

ER -

The effect of mycophenolic acid on the cell cycle of Candida albicans

Abstract

Keywords

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