@article{0f8e4a6a4839485593fbaa5d3c34425e,
title = "The Human Blood Fluke, Schistosoma mansoni, Harbors Bacteria Throughout the Parasite's Life Cycle",
abstract = "While symbiotic relationships between invertebrates and bacteria have been extensively described, studies of microbial communities inhabiting parasitic worms remain scarce. Exploring the microbiota associated with helminths responsible for major infectious diseases will inform on parasite biology, host-pathogen interactions, and disease pathophysiology. We investigated the presence of microorganisms inhabiting tissues of the human parasite Schistosoma mansoni. In situ hybridization using a pan-bacterial 16S rRNA gene probe revealed bacteria colonizing key developmental stages that were successfully removed after antibiotic treatment of live parasites. Understanding the composition and function of the S. mansoni-associated microbiota may lead to the development of novel microbiome-targeting control strategies.",
keywords = "fluorescence in situ hybridization, parasite-associated microbiota, schistosomes, Animals, Bacteria/genetics, Humans, Parasites/genetics, Schistosoma mansoni/genetics, RNA, Ribosomal, 16S/genetics, Helminths, Life Cycle Stages, Schistosomiasis mansoni/parasitology",
author = "Fabio Formenti and Alba Cort{\'e}s and Michela Deiana and Susannah Salter and Julian Parkhill and Matt Berriman and Gabriel Rinaldi and Cinzia Cantacessi",
note = "Funding Information: Financial support. This work was supported by the IRCCS Sacro Cuore Don Calabria, Verona Italy (MPhil scholarship to F. F.); UK Research and Innovation (UKRI; Future Leaders Fellowship to G. R.); and the Ministry of Health Italy Fondi Ricerca Corrente-L3, P2 to IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy. C. C.{\textquoteright}s laboratory is supported by the UKRI and the Isaac Newton Trust. Funding to pay the Open Access publication charges for this article was provided by the University of Cambridge. Funding Information: This work was supported by the IRCCS Sacro Cuore Don Calabria, Verona Italy (MPhil scholarship to F. F.); UK Research and Innovation (UKRI; Future Leaders Fellowship to G. R.); and the Ministry of Health Italy Fondi Ricerca Corrente-L3, P2 to IRCCS Sacro Cuore Don Calabria Hospital, Verona, Italy. C. C.{\textquoteright}s laboratory is supported by the UKRI and the Isaac Newton Trust. Funding to pay the Open Access publication charges for this article was provided by the University of Cambridge. Publisher Copyright: {\textcopyright} The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.",
year = "2023",
month = nov,
day = "1",
doi = "10.1093/infdis/jiad288",
language = "English",
volume = "228",
pages = "1299--1303",
journal = "The Journal of infectious diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "9",
}
