The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis

Margot A. Skinner; D. Neil Wedlock; Geoffrey W. De Lisle; Michèle M. Cooke; Ricardo E. Tascon; Jose C. Ferraz; Douglas B. Lowrie; H. Martin Vordermeier; R. Glyn Hewinson; Bryce M. Buddle

doi:10.1128/IAI.73.7.4441-4444.2005

The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis

Margot A. Skinner, D. Neil Wedlock, Geoffrey W. De Lisle, Michèle M. Cooke, Ricardo E. Tascon, Jose C. Ferraz, Douglas B. Lowrie, H. Martin Vordermeier, R. Glyn Hewinson, Bryce M. Buddle^*

^*Corresponding author for this work

Bovine TB, diseases and control

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp10, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity.

Original language	English
Pages (from-to)	4441-4444
Number of pages	4
Journal	Infection and Immunity
Volume	73
Issue number	7
Early online date	21 Jun 2005
DOIs	https://doi.org/10.1128/IAI.73.7.4441-4444.2005
Publication status	Published - 01 Jul 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1128/IAI.73.7.4441-4444.2005

Permanent link

Persistent link

Fingerprint

Dive into the research topics of 'The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis'. Together they form a unique fingerprint.

Cite this

Skinner, M. A., Wedlock, D. N., De Lisle, G. W., Cooke, M. M., Tascon, R. E., Ferraz, J. C., Lowrie, D. B., Vordermeier, H. M., Hewinson, R. G., & Buddle, B. M. (2005). The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. Infection and Immunity, 73(7), 4441-4444. https://doi.org/10.1128/IAI.73.7.4441-4444.2005

@article{2ee16375136147038b4db0ec5850b269,

title = "The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis",

abstract = "Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Gu{\'e}rin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp10, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity.",

author = "Skinner, {Margot A.} and Wedlock, {D. Neil} and {De Lisle}, {Geoffrey W.} and Cooke, {Mich{\`e}le M.} and Tascon, {Ricardo E.} and Ferraz, {Jose C.} and Lowrie, {Douglas B.} and Vordermeier, {H. Martin} and Hewinson, {R. Glyn} and Buddle, {Bryce M.}",

year = "2005",

month = jul,

day = "1",

doi = "10.1128/IAI.73.7.4441-4444.2005",

language = "English",

volume = "73",

pages = "4441--4444",

journal = "Infection and Immunity",

issn = "0019-9567",

publisher = "American Society for Microbiology",

number = "7",

}

Skinner, MA, Wedlock, DN, De Lisle, GW, Cooke, MM, Tascon, RE, Ferraz, JC, Lowrie, DB, Vordermeier, HM, Hewinson, RG & Buddle, BM 2005, 'The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis', Infection and Immunity, vol. 73, no. 7, pp. 4441-4444. https://doi.org/10.1128/IAI.73.7.4441-4444.2005

The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. / Skinner, Margot A.; Wedlock, D. Neil; De Lisle, Geoffrey W. et al.
In: Infection and Immunity, Vol. 73, No. 7, 01.07.2005, p. 4441-4444.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis

AU - Skinner, Margot A.

AU - Wedlock, D. Neil

AU - De Lisle, Geoffrey W.

AU - Cooke, Michèle M.

AU - Tascon, Ricardo E.

AU - Ferraz, Jose C.

AU - Lowrie, Douglas B.

AU - Vordermeier, H. Martin

AU - Hewinson, R. Glyn

AU - Buddle, Bryce M.

PY - 2005/7/1

Y1 - 2005/7/1

N2 - Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp10, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity.

AB - Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp10, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity.

UR - http://www.scopus.com/inward/record.url?scp=21544454118&partnerID=8YFLogxK

U2 - 10.1128/IAI.73.7.4441-4444.2005

DO - 10.1128/IAI.73.7.4441-4444.2005

M3 - Article

C2 - 15972546

AN - SCOPUS:21544454118

SN - 0019-9567

VL - 73

SP - 4441

EP - 4444

JO - Infection and Immunity

JF - Infection and Immunity

IS - 7

ER -

Skinner MA, Wedlock DN, De Lisle GW, Cooke MM, Tascon RE, Ferraz JC et al. The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. Infection and Immunity. 2005 Jul 1;73(7):4441-4444. Epub 2005 Jun 21. doi: 10.1128/IAI.73.7.4441-4444.2005

The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis

Abstract

UN SDGs

Access to Document

Permanent link

Other files and links

Fingerprint

Cite this