The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis

Margot A. Skinner; D. Neil Wedlock; Geoffrey W. De Lisle; Michèle M. Cooke; Ricardo E. Tascon; Jose C. Ferraz; Douglas B. Lowrie; H. Martin Vordermeier; R. Glyn Hewinson; Bryce M. Buddle

doi:10.1128/IAI.73.7.4441-4444.2005

The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis

Margot A. Skinner
, D. Neil Wedlock
, Geoffrey W. De Lisle
, Michèle M. Cooke
, Ricardo E. Tascon
, Jose C. Ferraz
, Douglas B. Lowrie
, H. Martin Vordermeier
, R. Glyn Hewinson
, Bryce M. Buddle^*

^*Corresponding author for this work

Bovine TB, diseases and control

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Guérin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp10, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity.

Original language	English
Pages (from-to)	4441-4444
Number of pages	4
Journal	Infection and Immunity
Volume	73
Issue number	7
Early online date	21 Jun 2005
DOIs	https://doi.org/10.1128/IAI.73.7.4441-4444.2005
Publication status	Published - 01 Jul 2005

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Skinner, M. A., Wedlock, D. N., De Lisle, G. W., Cooke, M. M., Tascon, R. E., Ferraz, J. C., Lowrie, D. B., Vordermeier, H. M., Hewinson, R. G., & Buddle, B. M. (2005). The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. Infection and Immunity, 73(7), 4441-4444. https://doi.org/10.1128/IAI.73.7.4441-4444.2005

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title = "The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis",

abstract = "Priming neonatal calves at birth with a Mycobacterium bovis bacillus Calmette-Gu{\'e}rin (BCG) vaccine and boosting with a DNA vaccine consisting of plasmids encoding mycobacterial antigens Hsp65, Hsp10, and Apa or the reverse prime-boost sequence induced similar levels of protection against experimental challenge with Mycobacterium bovis. When M. bovis was isolated from a thoracic lymph node following challenge, the two groups of calves given the prime-boost regimen had significantly lower numbers of M. bovis isolates than those vaccinated with BCG alone. These observations suggest that the exact sequence of administration of a prime-boost vaccination regimen in a neonatal animal model is not critical to the development of immunity.",

author = "Skinner, \{Margot A.\} and Wedlock, \{D. Neil\} and \{De Lisle\}, \{Geoffrey W.\} and Cooke, \{Mich{\`e}le M.\} and Tascon, \{Ricardo E.\} and Ferraz, \{Jose C.\} and Lowrie, \{Douglas B.\} and Vordermeier, \{H. Martin\} and Hewinson, \{R. Glyn\} and Buddle, \{Bryce M.\}",

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Skinner, MA, Wedlock, DN, De Lisle, GW, Cooke, MM, Tascon, RE, Ferraz, JC, Lowrie, DB, Vordermeier, HM, Hewinson, RG & Buddle, BM 2005, 'The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis', Infection and Immunity, vol. 73, no. 7, pp. 4441-4444. https://doi.org/10.1128/IAI.73.7.4441-4444.2005

The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. / Skinner, Margot A.; Wedlock, D. Neil; De Lisle, Geoffrey W. et al.
In: Infection and Immunity, Vol. 73, No. 7, 01.07.2005, p. 4441-4444.

Research output: Contribution to journal › Article › peer-review

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AU - Buddle, Bryce M.

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Skinner MA, Wedlock DN, De Lisle GW, Cooke MM, Tascon RE, Ferraz JC et al. The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis. Infection and Immunity. 2005 Jul 1;73(7):4441-4444. Epub 2005 Jun 21. doi: 10.1128/IAI.73.7.4441-4444.2005

The order of prime-boost vaccination of neonatal calves with Mycobacterium bovis BCG and a DNA vaccine encoding mycobacterial proteins Hsp65, Hsp70, and Apa is not critical for enhancing protection against bovine tuberculosis

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