The pathways of complement

Jonathan M. Aitken, Tim Clarke, Jonathan I. Timmis

Research output: Chapter in Book/Report/Conference proceedingConference Proceeding (Non-Journal item)

1 Citation (Scopus)


The natural world has developed very effective methods for dealing with pathogens that are invading an organism. By taking inspiration from the in-built, innate, response this paper develops a new algorithm that mimics activation path of the Alternative Pathway of Complement. The Alternative Pathway is triggered by cell surfaces. If the surfaces display safe characteristics then a strong suppression process prevents activation. In the case of non-safe surfaces a positive feedback loop rapidly identifies the location marking it for removal by phagocytosis.

Original languageEnglish
Title of host publicationArtificial Immune Systems - 7th International Conference, ICARIS 2008, Proceedings
PublisherSpringer Nature
Number of pages12
ISBN (Print)3540850716, 9783540850717
Publication statusPublished - 2008
Event7th International Conference on Artificial Immune Systems, ICARIS 2008 - Phuket, Thailand
Duration: 10 Aug 200813 Aug 2008

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume5132 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference7th International Conference on Artificial Immune Systems, ICARIS 2008
Period10 Aug 200813 Aug 2008


  • sialic acid
  • alternative pathway
  • matching function
  • attentive monitoring
  • polyanionic molecule


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