The phylogeny and population structure of Mycobacterium bovis in the British Isles

A. R. Allen*, J. Dale, C. McCormick, T. R. Mallon, E. Costello, S. V. Gordon, R. G. Hewinson, R. A. Skuce, N. H. Smith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

To further understand the epidemic of bovine tuberculosis in Great Britain, Northern Ireland and the Republic of Ireland, we identified 16 mutations that are phylogenetically informative for Mycobacterium bovis strains from these regions. We determined the status of these mutations among a collection of 501 strains representing the molecular diversity found in these three regions of the British Isles. The resulting linear phylogenies from each region were concordant, showing that the same lineage of M. bovis was present. The dominance of this lineage is unique within Europe, and suggests that in the past the populations were homogenous. Comparison of approximately 500 strains isolated in 2005 from each region by spoligotype and 5 locus VNTR profiling, revealed distinct differences in the genotype frequencies and sub-lineage makeup between each region. We concluded that whilst each region shared the same major phylogenetic lineage of M. bovis, more recent evolution had resulted in the development of region-specific populations. Regional differences in the M. bovis populations suggest that it may be possible to identify the movement of strains from one region to another.

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalInfection, Genetics and Evolution
Volume20
Early online date09 Aug 2013
DOIs
Publication statusPublished - 01 Dec 2013

Keywords

  • Britain and Ireland
  • Evolution
  • Mycobacterium bovis

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