The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer

Nuno Vale*, Maria J. Gouveia, Gabriel Rinaldi, Júlio Santos, Lúcio Lara Santos, Paul J. Brindley, José M.Correia da Costa

*Corresponding author for this work

Research output: Contribution to journalReview Articlepeer-review

14 Citations (SciVal)

Abstract

Urogenital schistosomiasis is a neglected tropical disease that can lead to bladder cancer. How urogenital schistosomiasis induces carcinogenesis remains unclear, although there is evidence that the human blood fluke Schistosoma haematobium, the infectious agent of urogenital schistosomiasis, releases estradiol-like metabolites. These kind of compounds have been implicated in other cancers. Aiming for enhanced understanding of the pathogenesis of the urogenital schistosomiasis-induced bladder cancer, here we review, interpret, and discuss findings of estradiol-like metabolites detected in both the parasite and in the human urine during urogenital schistosomiasis. Moreover, we predict pathways and enzymes that are involved in the production of these metabolites emphasizing their potential effects on the dysregulation of the tumor suppressor gene p53 expression during urogenital schistosomiasis. Enhanced understanding of these potential carcinogens may not only shed light on urogenital schistosomiasis-induced neoplasia of the bladder, but would also facilitate development of interventions and biomarkers for this and other infection-associated cancers at large.

Original languageEnglish
JournalTumor Biology
Volume39
Issue number3
DOIs
Publication statusPublished - 01 Mar 2017
Externally publishedYes

Keywords

  • bladder
  • estrogen-DNA adduct
  • estrogen-like metabolites
  • Schistosoma haematobium
  • squamous cell carcinoma
  • urogenital schistosomiasis
  • Reactive Oxygen Species/metabolism
  • Humans
  • Schistosomiasis haematobia/parasitology
  • Tumor Suppressor Protein p53/metabolism
  • Estradiol/metabolism
  • Cell Transformation, Neoplastic/pathology
  • Animals
  • Urinary Bladder/pathology
  • Urinary Bladder Neoplasms/metabolism
  • DNA Adducts/genetics
  • Schistosoma haematobium/metabolism

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