The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses

Colin M Fitzsimmons; Frances M Jones; Alex Stearn; Iain W Chalmers; Karl F Hoffmann; Jakub Wawrzyniak; Shona Wilson; Narcis B Kabatereine; David W Dunne

doi:10.1371/journal.pntd.0001593

The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses

Colin M Fitzsimmons
, Frances M Jones
, Alex Stearn
, Iain W Chalmers
, Karl F Hoffmann
, Jakub Wawrzyniak
, Shona Wilson
, Narcis B Kabatereine
, David W Dunne

Institute of Biological, Environmental, and Rural Sciences

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

153 Downloads (Pure)

Abstract

A human IgE response to Sm22.6 (a dominant IgE target in Schistosoma mansoni) is associated with the development of partial immunity. Located inside the tegument, the molecule belongs to a family of proteins from parasitic platyhelminths, the Tegument-Allergen-Like proteins (TALs). In addition to containing dynein-light-chain domains, these TALs also contain EF-hand domains similar to those found in numerous EF-hand allergens.

Original language	English
Article number	e1593
Journal	PLoS Neglected Tropical Diseases
Volume	6
Issue number	4
DOIs	https://doi.org/10.1371/journal.pntd.0001593
Publication status	Published - 03 Apr 2012

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Genome-Wide Prediction of Functional Gene-Gene Interactions Inferred from Patterns of Genetic Differentiation in Mice and MenFinal published version, 247 KB

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Fitzsimmons, C. M., Jones, F. M., Stearn, A., Chalmers, I. W., Hoffmann, K. F., Wawrzyniak, J., Wilson, S., Kabatereine, N. B., & Dunne, D. W. (2012). The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses. PLoS Neglected Tropical Diseases, 6(4), Article e1593. https://doi.org/10.1371/journal.pntd.0001593

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abstract = "A human IgE response to Sm22.6 (a dominant IgE target in Schistosoma mansoni) is associated with the development of partial immunity. Located inside the tegument, the molecule belongs to a family of proteins from parasitic platyhelminths, the Tegument-Allergen-Like proteins (TALs). In addition to containing dynein-light-chain domains, these TALs also contain EF-hand domains similar to those found in numerous EF-hand allergens.",

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AU - Hoffmann, Karl F

AU - Wawrzyniak, Jakub

AU - Wilson, Shona

AU - Kabatereine, Narcis B

AU - Dunne, David W

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AB - A human IgE response to Sm22.6 (a dominant IgE target in Schistosoma mansoni) is associated with the development of partial immunity. Located inside the tegument, the molecule belongs to a family of proteins from parasitic platyhelminths, the Tegument-Allergen-Like proteins (TALs). In addition to containing dynein-light-chain domains, these TALs also contain EF-hand domains similar to those found in numerous EF-hand allergens.

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The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses

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