TY - GEN
T1 - Towards argument-driven validation of an in silico model of immune tissue organogenesis
AU - Alden, Kieran
AU - Andrews, Paul S.
AU - Timmis, Jon
AU - Veiga-Fernandes, Henrique
AU - Coles, Mark
PY - 2011
Y1 - 2011
N2 - Specialised tissues of the immune system including lymph nodes, tonsils, spleen and Peyer's Patches have key roles in the initiation of adaptive immune responses to infection. To understand the molecular mechanisms involved in the development of this tissue, mice deficient for key genes in this process have been developed and analysed, leading to a basic model describing tissue formation. Although this approach has provided some key insights into the molecular mechanisms involved, due to the complexity of gene expression patterns it has not been possible to fully understand the process of lymphoid tissue organogenesis.
AB - Specialised tissues of the immune system including lymph nodes, tonsils, spleen and Peyer's Patches have key roles in the initiation of adaptive immune responses to infection. To understand the molecular mechanisms involved in the development of this tissue, mice deficient for key genes in this process have been developed and analysed, leading to a basic model describing tissue formation. Although this approach has provided some key insights into the molecular mechanisms involved, due to the complexity of gene expression patterns it has not been possible to fully understand the process of lymphoid tissue organogenesis.
UR - http://www.scopus.com/inward/record.url?scp=79960371508&partnerID=8YFLogxK
U2 - 10.1007/978-3-642-22371-6_7
DO - 10.1007/978-3-642-22371-6_7
M3 - Conference Proceeding (Non-Journal item)
AN - SCOPUS:79960371508
SN - 9783642223709
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 66
EP - 70
BT - Artificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings
T2 - 10th International Conference on Artificial Immune Systems, ICARIS 2011
Y2 - 18 July 2011 through 21 July 2011
ER -