Towards argument-driven validation of an in silico model of immune tissue organogenesis

Kieran Alden*, Paul S. Andrews, Jon Timmis, Henrique Veiga-Fernandes, Mark Coles

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference Proceeding (Non-Journal item)

3 Citations (SciVal)

Abstract

Specialised tissues of the immune system including lymph nodes, tonsils, spleen and Peyer's Patches have key roles in the initiation of adaptive immune responses to infection. To understand the molecular mechanisms involved in the development of this tissue, mice deficient for key genes in this process have been developed and analysed, leading to a basic model describing tissue formation. Although this approach has provided some key insights into the molecular mechanisms involved, due to the complexity of gene expression patterns it has not been possible to fully understand the process of lymphoid tissue organogenesis.

Original languageEnglish
Title of host publicationArtificial Immune Systems - 10th International Conference, ICARIS 2011, Proceedings
Pages66-70
Number of pages5
DOIs
Publication statusPublished - 2011
Event10th International Conference on Artificial Immune Systems, ICARIS 2011 - Cambridge, United Kingdom of Great Britain and Northern Ireland
Duration: 18 Jul 201121 Jul 2011

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume6825 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference10th International Conference on Artificial Immune Systems, ICARIS 2011
Country/TerritoryUnited Kingdom of Great Britain and Northern Ireland
CityCambridge
Period18 Jul 201121 Jul 2011

Fingerprint

Dive into the research topics of 'Towards argument-driven validation of an in silico model of immune tissue organogenesis'. Together they form a unique fingerprint.

Cite this