Two-Step Synthesis of Paracetamol (Acetaminophen), a Practical Illustration of Carbonyl Reactivity for Year-One Biosciences Students

Ifat Parveen*, Michael Rose, Helen C. Phillips, Stephen E. Flower, Timothy J. Woodman, Cameron A. Garty, Michael D. Threadgill

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4217 Downloads (Pure)

Abstract

An understanding of basic organic chemical reactivity is key for many biosciences students. The reactivities of different carbonyl groups affect their function in many biomolecules. A practical class, the two-step synthesis of paracetamol, has been devised to illustrate the electrophilic reactivities of carbonyls, which was covered in the accompanying lecture program. Students also examine the UV, IR, NMR, and mass spectra of the esters and amides, building further on the understanding gained in lectures. The practical work itself has been devised to be able to be run in bioscience laboratories with limited chemical facilities. The class has been enhanced during four academic years with strong support from the students.

Original languageEnglish
Pages (from-to)3955-3959
Number of pages5
JournalJournal of Chemical Education
Volume100
Issue number10
Early online date15 Sept 2023
DOIs
Publication statusPublished - 10 Oct 2023

Keywords

  • Adaptation to Limited Laboratory Facilities
  • Amides
  • Esters
  • First-Year Undergraduate/General
  • Hands-On Learning/Manipulatives
  • Integration of Spectroscopy
  • Organic Chemistry
  • Paracetamol
  • Reinforcement of Chemical Reactivity

Fingerprint

Dive into the research topics of 'Two-Step Synthesis of Paracetamol (Acetaminophen), a Practical Illustration of Carbonyl Reactivity for Year-One Biosciences Students'. Together they form a unique fingerprint.

Cite this