@article{0b05115c12d7440eb3e17b30c468335b,
title = "Whole-genome sequence of Schistosoma haematobium",
abstract = "Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.",
author = "Young, {Neil D.} and Jex, {Aaron R.} and Bo Li and Shiping Liu and Linfeng Yang and Zijun Xiong and Yingrui Li and Cinzia Cantacessi and Hall, {Ross S.} and Xun Xu and Fangyuan Chen and Xuan Wu and Adhemar Zerlotini and Guilherme Oliveira and Andreas Hofmann and Guojie Zhang and Xiaodong Fang and Yi Kang and Campbell, {Bronwyn E.} and Alex Loukas and Shoba Ranganathan and David Rollinson and Gabriel Rinaldi and Brindley, {Paul J.} and Huanming Yang and Jun Wang and Jian Wang and Gasser, {Robin B.}",
note = "Funding Information: This project was funded by the Australian Research Council (R.B.G. and H.M.Y.) and BGI. We are grateful for other support from the National Health and Medical Research Council (NHMRC) of Australia (R.B.G.), the Australian Academy of Science, the Australian-American Fulbright Commission, Melbourne Water Corporation, the Victorian Life Sciences Computation Initiative (VLSCI) and the IBM Collaboratory. N.D.Y. (Early Career Research Fellow) and A.R.J. (CDA1 Fellow) were supported by NHMRC fellowships. We thank staff of BGI-Shenzhen, including Q. Nan, P. Na, B. Min and P. Ni for their contributions. Schistosoma haematobium–infected hamsters were provided by F.A. Lewis and Y.-S. Liang of the Biomedical Research Institute, under NIAID-NIH contract HHSN272201000005I. G.O. is supported by NIH-Fogarty TW007012, FAPEMIG CBB-1181/08 and CNPq 573839/2008-5.",
year = "2012",
month = jan,
day = "15",
doi = "10.1038/ng.1065",
language = "English",
volume = "44",
pages = "221--225",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Springer Nature",
number = "2",
}
