Development of a Dictyostelium discoideum (slime mould) based rapid drug screening system to identify potential anti-protozoan drugs

Abstract

Dictyostelium discoideum is a free living social amoeba, which are able to change from a single celled organism to multicellular organism when in starvation condition. In this study, D. dicsoideum is being utilised as a model organism to screen over 400 compounds for activity against pathogenic protozoans. The technique evaluated using an agar based assay. Furthermore, three compounds were also identified as promising for further investigation for their anti-protozoan activity properties

Date of Award	2022
Original language	English
Awarding Institution	Aberystwyth University
Supervisor	Justin Pachebat (Supervisor) & Joanne Hamilton (Supervisor)